Failure of recognition of drug‐induced parkinsonism in the elderly
Identifieur interne : 002848 ( Main/Exploration ); précédent : 002847; suivant : 002849Failure of recognition of drug‐induced parkinsonism in the elderly
Auteurs : Christine D. Esper [Géorgie (pays)] ; Stewart A. Factor [Géorgie (pays)]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-02-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée.
English descriptors
- KwdEn :
- Aged, Antipsychotic, Antipsychotic Agents (adverse effects), Diagnosis, Elderly, Evaluation Studies as Topic, Female, Geriatric Assessment, Humans, Longitudinal Studies, Male, Metoclopramide, Nervous system diseases, Neurologic Examination, Parkinson Disease, Secondary (chemically induced), Parkinson disease, Parkinson's disease/parkinsonism, Parkinsonism, Retrospective Studies, atypical antipsychotics, diagnosis, drug‐induced parkinsonism, elderly, metoclopramide.
- MESH :
- chemical , adverse effects : Antipsychotic Agents.
- chemically induced : Parkinson Disease, Secondary.
- Aged, Evaluation Studies as Topic, Female, Geriatric Assessment, Humans, Longitudinal Studies, Male, Neurologic Examination, Retrospective Studies.
Abstract
Our objective was to evaluate the ability of neurologists to recognize and diagnose drug‐induced Parkinsonism (DIP) in the elderly. DIP is a diagnostic challenge because it can be indistinguishable from Parkinson's disease, especially in the elderly. It is frequently under‐recognized by psychiatrists and primary care physicians. Atypical antipsychotics (AA) are advertised for their low propensity to cause DIP. This may add to problems with recognition. We performed a retrospective record review of consecutive new parkinsonian patients seen over 2 years in a movement disorders clinic to examine the frequency, causative agents, and diagnostic accuracy of DIP by physicians, particularly neurologists. Of 354 Parkinsonian patients evaluated, 24 (6.8%) had DIP, 46% of these were due to AA and 29% were caused by metoclopramide. Of the 24 patients with DIP, only one was previously diagnosed accurately according to records. Nineteen patients (79%) were previously evaluated by a neurologist, and none of them was diagnosed with DIP. The primary reason for failure to recognize DIP relates to under‐recognition of AA as possible cause. A majority remained on the inciting agents while dopaminergic drugs were prescribed. DIP was reversible when the inciting drug was stopped. DIP is a common form of parkinsonism and is under‐recognized, even by neurologists. AA and metoclopramide do not appear to be well‐known to cause DIP. Cessation of the offending agent results in improvement of symptoms and would eliminate the need for dopaminergic agents, which are known to commonly cause side effects in the elderly. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21854
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001932
- to stream Istex, to step Curation: 001932
- to stream Istex, to step Checkpoint: 001404
- to stream PubMed, to step Corpus: 002410
- to stream PubMed, to step Curation: 002410
- to stream PubMed, to step Checkpoint: 002298
- to stream Ncbi, to step Merge: 001F49
- to stream Ncbi, to step Curation: 001F49
- to stream Ncbi, to step Checkpoint: 001F49
- to stream Main, to step Merge: 003426
- to stream PascalFrancis, to step Corpus: 001335
- to stream PascalFrancis, to step Curation: 001984
- to stream PascalFrancis, to step Checkpoint: 001255
- to stream Main, to step Merge: 003863
- to stream Main, to step Curation: 002848
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Failure of recognition of drug‐induced parkinsonism in the elderly</title>
<author><name sortKey="Esper, Christine D" sort="Esper, Christine D" uniqKey="Esper C" first="Christine D." last="Esper">Christine D. Esper</name>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9648D85B00B4BD30CECE0DB1EA9D2273A52AEF3A</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.21854</idno>
<idno type="url">https://api.istex.fr/document/9648D85B00B4BD30CECE0DB1EA9D2273A52AEF3A/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001932</idno>
<idno type="wicri:Area/Istex/Curation">001932</idno>
<idno type="wicri:Area/Istex/Checkpoint">001404</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Esper C:failure:of:recognition</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18067180</idno>
<idno type="wicri:Area/PubMed/Corpus">002410</idno>
<idno type="wicri:Area/PubMed/Curation">002410</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002298</idno>
<idno type="wicri:Area/Ncbi/Merge">001F49</idno>
<idno type="wicri:Area/Ncbi/Curation">001F49</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F49</idno>
<idno type="wicri:Area/Main/Merge">003426</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:08-0169569</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001335</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001984</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001255</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Esper C:failure:of:recognition</idno>
<idno type="wicri:Area/Main/Merge">003863</idno>
<idno type="wicri:Area/Main/Curation">002848</idno>
<idno type="wicri:Area/Main/Exploration">002848</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Failure of recognition of drug‐induced parkinsonism in the elderly</title>
<author><name sortKey="Esper, Christine D" sort="Esper, Christine D" uniqKey="Esper C" first="Christine D." last="Esper">Christine D. Esper</name>
<affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Department of Neurology, Emory University School of Medicine, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
<affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Department of Neurology, Emory University School of Medicine, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-02-15">2008-02-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="401">401</biblScope>
<biblScope unit="page" to="404">404</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">9648D85B00B4BD30CECE0DB1EA9D2273A52AEF3A</idno>
<idno type="DOI">10.1002/mds.21854</idno>
<idno type="ArticleID">MDS21854</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antipsychotic</term>
<term>Antipsychotic Agents (adverse effects)</term>
<term>Diagnosis</term>
<term>Elderly</term>
<term>Evaluation Studies as Topic</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Metoclopramide</term>
<term>Nervous system diseases</term>
<term>Neurologic Examination</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease/parkinsonism</term>
<term>Parkinsonism</term>
<term>Retrospective Studies</term>
<term>atypical antipsychotics</term>
<term>diagnosis</term>
<term>drug‐induced parkinsonism</term>
<term>elderly</term>
<term>metoclopramide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Evaluation Studies as Topic</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Neurologic Examination</term>
<term>Retrospective Studies</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Antipsychotique</term>
<term>Diagnostic</term>
<term>Maladie de Parkinson</term>
<term>Métoclopramide</term>
<term>Parkinsonisme</term>
<term>Pathologie du système nerveux</term>
<term>Personne âgée</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Our objective was to evaluate the ability of neurologists to recognize and diagnose drug‐induced Parkinsonism (DIP) in the elderly. DIP is a diagnostic challenge because it can be indistinguishable from Parkinson's disease, especially in the elderly. It is frequently under‐recognized by psychiatrists and primary care physicians. Atypical antipsychotics (AA) are advertised for their low propensity to cause DIP. This may add to problems with recognition. We performed a retrospective record review of consecutive new parkinsonian patients seen over 2 years in a movement disorders clinic to examine the frequency, causative agents, and diagnostic accuracy of DIP by physicians, particularly neurologists. Of 354 Parkinsonian patients evaluated, 24 (6.8%) had DIP, 46% of these were due to AA and 29% were caused by metoclopramide. Of the 24 patients with DIP, only one was previously diagnosed accurately according to records. Nineteen patients (79%) were previously evaluated by a neurologist, and none of them was diagnosed with DIP. The primary reason for failure to recognize DIP relates to under‐recognition of AA as possible cause. A majority remained on the inciting agents while dopaminergic drugs were prescribed. DIP was reversible when the inciting drug was stopped. DIP is a common form of parkinsonism and is under‐recognized, even by neurologists. AA and metoclopramide do not appear to be well‐known to cause DIP. Cessation of the offending agent results in improvement of symptoms and would eliminate the need for dopaminergic agents, which are known to commonly cause side effects in the elderly. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Géorgie (pays)</li>
</country>
</list>
<tree><country name="Géorgie (pays)"><noRegion><name sortKey="Esper, Christine D" sort="Esper, Christine D" uniqKey="Esper C" first="Christine D." last="Esper">Christine D. Esper</name>
</noRegion>
<name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002848 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002848 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:9648D85B00B4BD30CECE0DB1EA9D2273A52AEF3A |texte= Failure of recognition of drug‐induced parkinsonism in the elderly }}
This area was generated with Dilib version V0.6.23. |